The Markus Lab

Molecular motors and mitosis


Relevant Publications:




Ecklund KH, Morisaki T, Lammers LG, Marzo MG, Stasevich TJ, and Markus SM. She1 affects dynein through direct interactions with the microtubule and the dynein microtubule-binding domain. Nature Communications, 8, Article number: 2151 (2017). (Download PDF)

Heasley LR, Markus SM, and DeLuca JG. “Wait anaphase”

signals are not confined to the mitotic spindle. Mol Biol Cell.

2017 May 1; 28(9): 1186-94. (Download PDF)

        Featured on the cover!

Lammers LG and Markus SM. The dynein cortical anchor Num1 activates dynein motility by relieving Pac1/LIS1-mediated inhibition. J Cell Biol. 2015 Oct 26; 211(2): 309-322. (Download PDF)

        Highlighted in J Cell Biol!

Markus SM, Omer S, Baranowski K, and Lee WL. Improved Plasmids for Fluorescent Protein Tagging of Microtubules in Saccharomyces cerevisiae. Traffic. 2015 Jul; 16(7):773-86. (Download PDF)

Markus SM, Kalutkiewicz KA and Lee WL. Astral microtubule asymmetry provides directional cues for spindle positioning in budding yeast. Exp Cell Res. 2012 Jul; 318(12): 1400-06. (Download PDF)

Markus SM, Kalutkiewicz KA, and Lee WL. She1-mediated inhibition of dynein motility along astral microtubules promotes unidirectional spindle movements. Curr Biol, 2012, 22: 2221-2230. (Download PDF)

Markus SM, Plevock KM, St. Germain BJ, Punch JJ, Meaden CW, Lee WL. Quantitative Analysis of Pac1/LIS1-mediated Dynein Targeting: Implications for Regulation of Dynein Activity in Budding Yeast. Cytoskeleton. 2011 Mar; 68(3): 157-74. (Download PDF)

Markus SM and Lee WL. Regulated Offloading of Cytoplasmic Dynein from Microtubule Plus Ends to the Cortex. Dev Cell. 2011 May; 20(5):639-651. (Download PDF)

Markus SM and Lee WL. Microtubule-dependent Path to the Cell Cortex for Cytoplasmic Dynein in Mitotic Spindle Orientation. Bioarchitecture. 2011 September/October; 1(5): 209-215. (Download PDF)

Markus SM, Punch JJ, Lee WL. Motor and Tail Dependent Targeting of Dynein to Microtubule Plus-Ends and the Cell Cortex. Curr Biol. 2009 Jan; 19(3):196-205. (Download PDF)

Vorvis C, Markus SM, Lee WL. Photoactivatable GFP tagging cassettes for protein-tracking studies in the budding yeast Saccharomyces cerevisiae. Yeast. 2008 Sep; 25(9):651-9. (Download PDF)